Two hormones (estrogen and progesterone) fluctuate throughout the course of the menstrual cycle which can lead to a change in seizure frequency.
Catamenial epilepsy is the clustering of seizures in alignment with the female reproductive cycle. Two predominant patterns of catamenial seizures are seen, perimenstrual and periovulatory, with the perimenstrual pattern being more common.
Seizure frequency is linked to the ratio of serum estradiol to progesterone with higher ratios leading to clustering. This ratio is highest during the premenstrual period (secondary to the rapid withdrawal of progesterone) and the days preceding ovulation (secondary to the rapid, steep increase in serum estradiol.
There are various treatments for the treatment of catamenial seizures and we can discuss different strategies in detail during your visit.